![]() ![]() 6,7 Taking opioids in combination with xylazine and other central nervous system depressants-like alcohol or benzodiazepines-increases the risk of life-threatening overdose. 7Īlso known as “tranq,” 5 xylazine is a central nervous system depressant that can cause drowsiness and amnesia and slow breathing, heart rate, and blood pressure to dangerously low levels. 1 Most overdose deaths linked to both xylazine and fentanyl also involved additional substances, including cocaine, heroin, benzodiazepines, alcohol, gabapentin, 3 methadone, and prescription opioids. Research has shown xylazine is often added to illicit opioids, including fentanyl, 3and people report using xylazine-containing fentanyl to lengthen its euphoric effects. ![]() Xylazine was involved in 19% of all drug overdose deaths in Maryland in 2021 and 10% in Connecticut in 2020. ![]() From 2015 to 2020, the percentage of all drug overdose deaths involving xylazine increased from 2% to 26% in Pennsylvania. While the full national scope of overdose deaths involving xylazine is unknown, research shows overdose deaths linked to xylazine have spread westward across the United States, with the largest impact in the Northeast. 1 Studies show people exposed to xylazine often knowingly or unknowingly used it in combination with other drugs, particularly illicit fentanyl. Xylazine, a non-opioid veterinary tranquilizer not approved for human use, has been linked to an increasing number of overdose deaths nationwide in the evolving drug addiction and overdose crisis. ![]()
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